Équipe B. Dargent

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Axonal Domains Architecture Team (B. Dargent)

The axonal initial segment (AIS) is a unique sub-domain that plays a central role in the physiology of the neuron. It orchestrates both electrogenesis and the maintenance of neuronal polarity and the AIS is capable of homeostatic plasticity through an activity –dependent change in either its location or morphology.

The goal of our work consists in deciphering the complex and dynamic mechanisms accounting for the assembly and the maintenance of the AIS, both in vivo and in cultured hippocampal neurons. Finally, the role of these mechanisms in AIS plasticity is also actively explored.

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