Interfaces Cliniques

M. Bouvier Team

We study the motility of digestive tract in mammals, during inflammatory processes, in physiological and pathological conditions. Studies are carried out on the integrative properties of visceral afferences and prevertebral ganglia, in order to precise their role in the organisation of regulatory reflexes in digestive motility, on both animal and man. In animals, we use electrophysiology to study the effect of substances, implicated in food intake and inflammation, on vagal afferences and ganglionic neurons discharges.

Using molecular biology, we analyse the expression of the enzyme responsible for prostaglandin synthesis in colon and ileum pieces coming from humans affected by crohn disease or animals having experimental inflammation. We are also interested in somato-visceral reflexes controlling colonic motility and fecal continence. These studies present a great interest in human pathologies care.

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