PPSN

Research interests

The research of the team is focused on the maturation and the plasticity of the central respiratory network, i.e., the whole nervous cells responsible for the elaboration and the regulation of respiratory movements, and on the role of neurotransmitters in these processes. Studies are performed on fetuses, newborns and adults of Mammals, and especially on mice, either wild type mice or transgenic ones. The team is using a large panel of different but complementary approaches (in vivo plethysmography, in vitro preparations, in situ preparation, electrophysiology, immunohistochemistry, cellular and molecular biology, biochemistry, microsurgery, olfactive glial cells transplantation, etc.).

The aim of the MP3-Respiration research is :
- to define the role of genetic factors in the maturation and function of the respiratory network, via a post-genomic approach, with the view of improving our knowledge on the mechanisms responsible for breathing deficits accompanying some rare diseases (Rett Syndrome, Prader Willi Syndrome, Sudden Infant Death Syndrome) and/or more frequent diseases (Sleep Apneas Syndrome),
- to analyze the role of environmental factors during gestation and/or the early postnatal period on the respiratory network maturation (hypoxia, medicaments, drug abuse, stressful situation, etc..) as well as on sequels during adulthood,
- to develop new therapeutic approaches to compensate, at least in part, the respiratory deficits due to genetic and environmental factors and traumas (spinal cord injury in adults),
- to study the long lasting sequels due to a poor oxygenation during the perinatal period on the maturation of central networks other than the respiratory one and on possible dysfunction in memory, sleep, food intake, etc.. during adulthood,
- to study the interactions between the respiratory network and other brainstem neural networks to analyze the mechanisms underlying networks functional plasticity. To conclude, the MP3-Respiration team is performing fundamental researches on the central respiratory network which will improve our knowledge in the field and might be useful in Human care and Health domains.

Voir en ligne : Laboratoire de Physiologie Neurovégétative

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