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Accueil > Bibliographie > Total synthesis of mololipids : a new series of anti-HIV Moloka’iamine (...)

Total synthesis of mololipids : a new series of (...)

Bioorg Med Chem Lett. 2000 Dec ;10(23):2679-81
Total synthesis of mololipids : a new series of anti-HIV Moloka’iamine derivatives.
Schoenfeld RC, Lumb JP, Fantini J, Ganem B.

A new family of bioactive bromotyrosine derivatives, termed mololipids, was recently isolated from a Hawaiian sponge, but could not be resolved into individual components by chromatography. To complete their structural characterization and better understand structure-activity relationships, the first pure samples of dimyristoyl, distearoyl, dioleoyl, and stearoyl/oleoyl mololipids have now been prepared by total synthesis, and their anti-HIV activity investigated.

PubMed

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