Plates-formes PFRN

Accueil > Bibliographie > Thyroid hormone action in cerebellum and cerebral cortex development.

Thyroid hormone action in cerebellum and cerebral (...)

J Thyroid Res. 2011 ;2011:145762
Thyroid hormone action in cerebellum and cerebral cortex development.
Chatonnet F, Picou F, Fauquier T, Flamant F.

Thyroid hormones (TH, including the prohormone thyroxine (T4) and its active deiodinated derivative 3,3’,5-triiodo-L-thyronine (T3)) are important regulators of vertebrates neurodevelopment. Specific transporters and deiodinases are required to ensure T3 access to the developing brain. T3 activates a number of differentiation processes in neuronal and glial cell types by binding to nuclear receptors, acting directly on transcription. Only few T3 target genes are currently known. Deeper investigations are urgently needed, considering that some chemicals present in food are believed to interfere with T3 signaling with putative neurotoxic consequences.

PubMed

    Ils nous font confiance

  • logo amu
  • logo cnrs
  • logo inserm
  • logo AP-HM
  • logo F�d�ration pour la Recherche sur le Cerveau
  • logo Fondation pour la Recherche Medical en France
  • logo IBiSA
  • logo Europe programme FEDER
  • logo Agence Nationale de la Recherche
  • logo Plateforme Technologique Aix-Marseille
  • logo Vect-Horus
  • logo Neuron Experts