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Accueil > Bibliographie > The scorpion toxin Bot IX is a potent member of the α-like family and has a (...)

The scorpion toxin Bot IX is a potent member of the (...)

FEBS Lett. 2016 Sep ;590(18):3221-32
The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension.
Martin-Eauclaire MF, Salvatierra J, Bosmans F, Bougis PE.

We report the detailed chemical, immunological and pharmacological characterization of the α-toxin Bot IX from the Moroccan scorpion Buthus occitanus tunetanus venom. Bot IX, which consists of 70 amino acids, is a highly atypical toxin. It carries a unique N-terminal sequence extension and is highly lethal in mice. Voltage clamp recordings on oocytes expressing rat Nav1.2 or insect BgNav1 reveal that, similar to other α-like toxins, Bot IX inhibits fast inactivation of both variants. Moreover, Bot IX belongs to the same structural/immunological group as the α-like toxin Bot I. Remarkably, radioiodinated Bot IX competes efficiently with the classical α-toxin AaH II from Androctonus australis, and displays one of the highest affinities for Nav channels.

PubMed

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