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Accueil > Bibliographie > The role of hyperpolarization-activated cationic current in spike-time (...)

The role of hyperpolarization-activated cationic (...)

J Physiol. 2011 Aug ;589(Pt 15):3753-73
The role of hyperpolarization-activated cationic current in spike-time precision and intrinsic resonance in cortical neurons in vitro.
Gastrein P, Campanac E, Gasselin C, Cudmore RH, Bialowas A, Carlier E, Fronzaroli-Molinieres L, Ankri N, Debanne D.

Non-technical summary  We determined here the role of the hyperpolarization-activated cationic (h) current on the temporal organization of hippocampal activity in vitro. In CA1 pyramidal neurons the h-current has three main actions. In addition to setting intrinsic resonance frequency at ∼4 Hz, the h-current determines, through two main mechanisms, the temporal precision of action potentials evoked by excitatory postsynaptic potentials or following stimulation of inhibitory postsynaptic potentials (rebound spiking). We propose that h-channels participate in the fine tuning of oscillatory activity in hippocampal and neocortical networks.


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