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Somatostatin receptor sst2 gene transfer in human (...)

Mol Cell Endocrinol. 2012 May ;355(1):106-13
Somatostatin receptor sst2 gene transfer in human prolactinomas in vitro : impact on sensitivity to dopamine, somatostatin and dopastatin, in the control of prolactin secretion.
Cuny T, Mohamed A, Graillon T, Roche C, Defilles C, Germanetti AL, Couderc B, Figarella-Branger D, Enjalbert A, Barlier A, Saveanu A.

As prolactinomas fail to respond to dopamine agonist (DA) in 10-20% of cases, we hypothesized that somatostatin subtype 2 receptor (sst2) overexpression in DA-resistant prolactinomas may enhance suppression of prolactine (PRL) using chimeric agonist (dopastatin) that simultaneously binds sst2 and the dopamine subtype 2 receptor (D2DR).

PubMed

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