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Selective transport of staphylococcal enterotoxin A (...)

Microbes Infect. 2007 Oct ;9(12-13):1507-10
Selective transport of staphylococcal enterotoxin A through in vitro generated human M cells.
Maresca M, Dumay E, Fantini J, Caporiccio B.

Staphylococcal enterotoxins are responsible for food poisoning and toxic shock syndrome due to their superantigen activity on T cells. Although their activity necessarily involves passage through the intestinal epithelium, little is known about this critical step. In the present study, we compared the in vitro transport of staphylococcal enterotoxin A through human intestinal absorptive and M cells. We found that the transport of the toxin through M cells was polarized and temperature-sensitive, in contrast with the less efficient transport of the toxin by absorptive cells. These data suggest the involvement of M cells in the intestinal absorption of staphylococcal enterotoxins.

PubMed

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