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Accueil > Bibliographie > Plasma levels of interferon-gamma correlate with age-related disturbances (...)

Plasma levels of interferon-gamma correlate with (...)

Chronobiol Int. 2009 Dec ;26(8):1587-601
Plasma levels of interferon-gamma correlate with age-related disturbances of circadian rhythms and survival in a non-human primate.
Cayetanot F, Nygard M, Perret M, Kristensson K, Aujard F.

Aging can be associated with changes in circadian rhythms and reduction in adaptive immune responses accompanied by expansion of memory T cells and elevated levels of pro-inflammatory cytokines. Recent findings suggest the cytokine interferon-gamma (IFN-gamma) can affect the function of the hypothalamic suprachiasmatic nucleus (SCN), the master mammalian circadian pacemaker, both in vitro and in vivo. We studied the correlation of plasma levels of IFN-gamma and changes in circadian rhythms in a non-human primate species, the nocturnal mouse lemur (Microcebus murinus). Plasma IFN-gamma and dehydroepiandrosterone sulfate (DHEA-S), a known biomarker of aging, were determined in middle- to old-age animals by immunoenzymoassay. Daily rhythms of locomotor activity and body temperature as well as survival time of the lemurs were recorded. With aging, mean levels of DHEA-S decreased whereas IFN-gamma increased. Aged animals showed biological rhythm alterations characterized by a high percentage of diurnal activity, anticipation of the activity onset relative to lights-off, short free-running period, and delayed occurrence of minimal body temperature. The magnitude of these disturbances was correlated with the plasma level of IFN-gamma but not DHEA-S. Most remarkably, in contrast to DHEA-S, increased levels of IFN-gamma correlated with duration of the lifetime of the lemurs. These results show the degree of circadian rhythm alterations in an individual is correlated with plasma IFN-gamma level during aging, and that plasma IFN-gamma level may predict survival, at least in this non-human primate.


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