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Longitudinal monitoring of the serotonin transporter (...)

Neuropsychobiology. 2014 ;70(4):220-7
Longitudinal monitoring of the serotonin transporter gene expression to assess major depressive episode evolution.
Belzeaux R, Loundou A, Azorin JM, Naudin J, Ibrahim EL C.

Mood disorders are frequently characterized by uncertain prognosis and studying mRNA expression variations in blood cells represents a promising avenue of identifying biomarkers for mood disorders. State-dependent gene expression variations have been described during a major depressive episode (MDE), in particular for SLC6A4 mRNA, but how this transcript varies in relation to MDE evolution remains unclear. In this study, we prospectively assessed time trends of SCL6A4 mRNA expression in responder and nonresponder patients.


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