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K(+) channel blocker-induced neuroinflammatory response (...)

Inflamm Res. 2016 Aug ;65(8):623-34
K(+) channel blocker-induced neuroinflammatory response and neurological disorders : immunomodulatory effects of astaxanthin.
Sifi N, Martin-Eauclaire MF, Laraba-Djebari F.

Channelopathies due to the brain ion channel dysfunction is considered to be an important mechanism involved in various neurodegenerative diseases. In this study, we evaluated the ability of kaliotoxin (KTX) as K(+) channel blocker to induce neuro-inflammatory response and neurodegenerative alteration. We also investigate the effects of astaxanthin (ATX) against KTX disorders.


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