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Intrathecal synthesis of IgM measured after a first (...)

Mult Scler. 2012 May ;18(5):587-91
Intrathecal synthesis of IgM measured after a first demyelinating event suggestive of multiple sclerosis is associated with subsequent MRI brain lesion accrual.
Durante L, Zaaraoui W, Rico A, Crespy L, Wybrecht D, Faivre A, Reuter F, Malikova I, Pommier G, Confort-Gouny S, Cozzone PJ, Ranjeva JP, Pelletier J, Boucraut J, Audoin B.

Previous studies have demonstrated that intrathecal synthesis of IgM is observed in multiple sclerosis (MS) and correlates with a worse disease course. These results suggest that IgM participates in the formation of MS lesions.

PubMed

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