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Accueil > Bibliographie > In vitro antiviral activities of extracts derived from Daucus maritimus (...)

In vitro antiviral activities of extracts derived from (...)

Nat Prod Res. 2011 Sep ; [Epub ahead of print]
In vitro antiviral activities of extracts derived from Daucus maritimus seeds.
Miladi S, Abid N, Debarnot C, Damak M, Canard B, Aouni M, Selmi B.

The antiviral activities of extracts from Daucus maritimus seeds were investigated against the reverse transcriptase of human immunodeficiency virus (HIV) type 1 and a panel of RNA-dependent RNA polymerases of dengue virus, West Nile virus (WNV) and hepatitis C virus (HCV). The extracts showed moderate to potent inhibition rates against the four viral polymerases. The ethyl acetate extract exhibited a potent inhibitory effect against WNV’s RdRp, with an IC(50) value of 8 µg mL(-1). The F (2) fraction exhibited potent inhibitory activity against WNV and HCV’s RdRps, with IC(50) values 1 and 5 µg mL(-1), respectively. The P (2) fraction also showed potent inhibitory effects on WNV and HCV’s RdRps, with IC(50) values 2.7 and 4 µg mL(-1), respectively. The results suggest that these extracts are candidates for the development of new anti-WNV RpDp and anti-HCV RpDp agents.

PubMed

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