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Fenretinide-induced caspase-8 activation and apoptosis (...)

BMC Cancer. 2009 ;9:97
Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.
Raguenez G, Muhlethaler-Mottet A, Meier R, Duros C, Benard J, Gross N.

Resistance of high-risk metastatic neuroblastoma (HR-NB) to high dose chemotherapy (HD-CT) raises a major therapeutic challenge in pediatric oncology. Patients are treated by maintenance CT. For some patients, an adjuvant retinoid therapy is proposed, such as the synthetic retinoid fenretinide (4-HPR), an apoptotic inducer. Recent studies demonstrated that NB metastasis process is enhanced by the loss of caspase-8 involved in the Integrin-Mediated Death (IMD) process. As the role of caspase-8 appears to be critical in preventing metastasis, we aimed at studying the effect of 4-HPR on caspase-8 expression in metastatic neuroblasts.

PubMed

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