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Conditional genome engineering in Toxoplasma gondii (...)

Nat Methods. 2013 Feb ;10(2):125-7
Conditional genome engineering in Toxoplasma gondii uncovers alternative invasion mechanisms.
Andenmatten N, Egarter S, Jackson AJ, Jullien N, Herman JP, Meissner M.

We established a conditional site-specific recombination system based on dimerizable Cre recombinase-mediated recombination in the apicomplexan parasite Toxoplasma gondii. Using a new single-vector strategy that allows ligand-dependent, efficient removal of a gene of interest, we generated three knockouts of apicomplexan genes considered essential for host-cell invasion. Our findings uncovered the existence of an alternative invasion pathway in apicomplexan parasites.


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