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Accueil > Bibliographie > 18F-FDG PET/CT as a predictor of hereditary head and neck paragangliomas.

18F-FDG PET/CT as a predictor of hereditary head and (...)

Eur J Clin Invest. 2014 Mar ;44(3):325-32
18F-FDG PET/CT as a predictor of hereditary head and neck paragangliomas.
Blanchet EM, Gabriel S, Martucci V, Fakhry N, Chen CC, Deveze A, Millo C, Barlier A, Pertuit M, Loundou A, Pacak K, Taieb D.

Hereditary head and neck paragangliomas (HNPGLs) account for at least 35% of all HNPGLs, most commonly due to germline mutations in SDHx susceptibility genes. Several studies about sympathetic paragangliomas have shown that (18)F-FDG PET/CT was not only able to detect and localize tumours, but also to characterize tumours ((18)F-FDG uptake being linked to SDHx mutations). However, the data concerning (18)F-FDG uptake specifically in HNPGLs have not been addressed. The aim of this study was to evaluate the relationship between (18)F-FDG uptake and the SDHx mutation status in HNPGL patients.

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