Accueil > Bibliographie > αv integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 (...)

αv integrin processing interferes with the cross-talk (...)

Biol Cell. 2011 Nov ;103(11):519-29
αv integrin processing interferes with the cross-talk between αvβ5/β6 and α2β1 integrins.
Defilles C, Montero MP, Lissitzky JC, Rome S, Siret C, Luis J, Andre F, Rigot V.

Previous studies have reported that cross-talk between integrins may be an important regulator of integrin-ligand binding and subsequent signalling events that control a variety of cell functions in many tissues. We previously demonstrated that αvβ5/β6 integrin represses α2β1-dependent cell migration. The αv subunits undergo an endoproteolytic cleavage by protein convertases, whose role in tumoral invasion has remained controversial.

PubMed

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