Plates-Formes de Recherche en Neurosciences

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Accueil > Agenda > Les séminaires Jean Roche > Probing the structure and function of circuits interfacing the spine with (...)

Probing the structure and function of circuits (...)

Sensory systems transduce fluctuations in the physical world into patterns of action potentials which are integrated to control motor outputs. Locomotion relies on genetically determined circuits constituted by spinal interneurons and capable of generating oscillations. Local sensory information about the outside world or the internal state are thought to alter these motor patterns by triggering, stopping or steering locomotion but the mechanisms are not fully understood. We study dynamic sensory-motor integration in spinal circuits of the tractable genetic model organism, zebrafish. The transparency of the larva enables to measure and manipulate sensory inputs with light in moving animals. In previous work, we developed in vivo optogenetic approaches for probing spinal circuits. We identified a new proprioceptive pathway interfacing the spinal circuits with the cerebrospinal fluid (CSF). We demonstrated that remote activation of this pathway could trigger slow locomotion. We now combine optogenetics, population imaging, electrophysiology and quantitative analysis of behaviour in order to elucidate this novel proprioceptive function at the molecular and circuit level.

Claire Wyart, PhD

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