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Accueil > Agenda > Les séminaires Jean Roche > Building of amyloid plaques in the brain ; a study based on interaction (...)

Building of amyloid plaques in the brain ; a study (...)

Horaire : 11 heures

Localisation : IFR Jean Roche de Neurosciences,

Nouvelle salle de conférence rdc nord bât. E secteur Nord de la Faculté de Médecine, CS 80011, 51 bd. Pierre Dramard 13 344 Marseille cedex 15.

Téléphone - télécopie : 04 91 69 87 25 , courriel : ifr.jr jean-roche.univ-mrs.fr

The amyloid-β peptide42 (Aβ42) is a key constituent of amyloid plaques in Alzheimer’s disease, Down’s syndrome and normal aging. The mechanism by which Aβ42 plaques are formed is not completely understood. Notably, we still lack an understanding of the factors that dictate Aβ42 fibrillogenesis, i.e., the process by which protofibrils combine to form deposits that can be recognized at the light or electron microscopic level. Several studies have proposed that Aβ42 binds to the cell surface via direct membrane interactions, thereby initiating neurotoxicity and plaque formation. Some data suggest that Aβ42 deposition is initiated in a plasma membrane-bound form, resulting in diffuse plaque formation. (Yamaguchi et al., 2000).

Also in models of early Alzheimer disease, membrane bound Aβ42 has been observed and interpreted as a possible site for plaque formation (Torp et al., 2003, Nuntagij et al. 2009). Aβ42 fibrillogenesis will be discussed based on results from three-dimensional reconstruction of serial ultrathin section and

detection of amyloid fibrils by high resolution postembedding immunocytochemistry and in vivo imaging to illustrate nascent amyloid plaques.

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